AMCIS 2022 will acknowledge that developments in information processing and communication technologies have occasioned broad changes to organizations as well as to research and the examination and studies of phenomena in organizations. The changes in systems include the views of the hardware of information systems (from devices for computing to devices enabling information and communication), the software (from being discrete applications to becoming the infrastructure for ubiquitous connections, processing, analytics and decision making) and the data (from being structured to the wide variety of unstructured and structured media content).  These changes clearly have occasioned complex transformations in how businesses operate and create value and require significant changes to the practice of academic research as well.